full FINAL Programme May 29-June 2 MASTER DEGREE PROJECT PRESENTATIONS VT23 MolMed o IMIM.docx

MASTER DEGREE PROJECT PRESENTATIONS VT23

Master’s in Molecular Medicine and Innovative Medicine

29 May -2 June 2023

Fåhraeussalen, Rudbeck Laboratory, Uppsala University

MAY 29

8.55- Welcome - attendance

9.00-9.40 Mapping the temporal course of CSF GAP-43 in Alzheimer’s disease

Speaker: Prithvi Arunachalam, Gothenburg University

Opponents: Patrizia and Alice

9.40 -10.20 Spatial analysis of clonality in the neural crest lineage in vivo

Speaker: Anthi Chalou, Karolinska Institute
Opponents: Alexandra and Matthijs

Break 15 min

10.35- 11.15 Characterization of CHO-M clones in relation to IgG1-GFP productivity

Speaker: Aisha Pereira Badji, Cytiva, Uppsala
Opponents: Faidra and Aoun

11.15- 11.55 Characterization of combination therapy in mouse colon cancer cell line models

Speaker: Ingrid Vallin, Uppsala University
Opponents: Saskia and Naixuan
LUNCH

13.00- 13.40 Simultaneous DNA-RNA FISH to study DNA-RNA interactions

Speaker: Laxmipriya Ramesh, Karolinska Institute
Opponents: Eva and Aileen

13.40- 14.20

Identification of novel drug candidates for the treatment of childhood neuroblastoma by spheroid-based chemical library screening

Speaker: Emma Lindell, Uppsala University

Opponents: Najma and Yersultan

Break 15 min

14.35- 15.15 Exploring the potential of urinary shed cells as a non-invasive source of human kidney tissue

Speaker: Izannery Izabaux Leoncio da Silva, Astra Zeneca, Gothenburg

Opponents: Rebeca and Kristian

15.15-15.55 Predicting and Targeting Treatment Resistance in Glioblastoma: Investigating the Potentials of SOX9 as a Specific Target of Suicide Gene Therapy

Speaker: Elin Vikström, Uppsala University

Opponents: Sophia and Ajla

16.05-16.45 In silico Discovery of Patient Tumor Immune Archetypes from single cell RNA-seq data

Speaker: Anna Culinscaia, GenMab, Utrecht

Opponents: Mantautas and Victoria

MAY 30

9.00- 9.40 Modeling cerebral cavernous malformations using patient-derived iPSC-based blood vessel organoids

Speaker: Neeharika Senthilkumar, Uppsala University

Opponents: Aoun and Najma

9.40 -10.20 CAR-T cell tonic signaling

Speaker: Paula Martí Torrell, Uppsala University
Opponents: Alexandra and Kristian

Break 15 min

10.35- 11.15

Enabling prediction of the impact of breast cancer resistance protein (BCRP)-mediated efflux on oral drug absorption in fresh rat and human intestinal tissue using a unique ex vivo method

Speaker: Aileen Uy, Astra Zeneca, Gothenburg
Opponents: Patrizia and Alice

11.15- 11.55

Developing molecular tools to detect and sort extracellular vesicles using proximity ligation assay

Speaker: George Mickhael Harinck, Uppsala University

Opponents: Matthijs and Rebeca

LUNCH

13.00- 13.40 In-vivo detection of amyloid-beta deposits with bispecific, brain penetrating antibodies

Speaker: Tiffany Dallas, Uppsala University

Opponents: Yersultan and Naixuan

13.40- 14.20 A general protocol of single nuclei isolation for Formalin-Fixed Paraffin-Embedded samples

Speaker: Minglu Xie, Uppsala University

Opponents: Faidra and Aisha

Break 15 min

14.35- 15.15 Characterisation of a novel substrate for the rhomboid protease RHBDL2

Speaker: Ajla Dzanko, Oxford University, UK

Opponents: Saskia and Eva

15.15-15.55 The role of extracellular matrix stiffness and PAK4 in breast cancer

Speaker: Mantautas Simkus, Karolinska Institute

Opponents: Sofie and Ingrid

16.05-16.45 Role of METTL5 in tumor cell plasticity in breast cancer

Speaker: Maria Victoria Chacon Quintero, New York University, USA

Opponents: Prithvi and Anthi

MAY 31

9.00- 9.40

Development of ExCirc probe and evaluation of mRNA detection efficiency

Speaker: Kristian Eriksson, Uppsala University

Opponents: Tiffany and Victoria

9.40 -10.20 Mechanistic investigation of immune checkpoint blockade in vitro and in vivo

Speaker: Rebeca Parracho, Uppsala University
Opponents: Ingrid and Emma

Break 15 min

10.35- 11.15 Development of a Semiparametric Mixture Approach (SMA) to accurately predict treatment effect

Speaker: Yersultan Mirasbekov, Uppsala University

Opponents: Izannery and Elin

11.15- 11.55

Semliki Forest virus-based intranasal immunotherapy against glioblastoma

Speaker: Sofie Brosch, Uppsala University

Opponents: Anna and Neeharika

LUNCH

13.00- 13.40 The role of IFIHl in pancreatic islet development and type 1 diabetes onset

Speaker: Sophia Forsskåhl, Helsinki University
Opponents: Paula and Aileen

13.40- 14.20 Revealing the molecular mechanism of gasdermin membrane pore formation

Speaker: Najma Omar Mohamud, Uppsala University

Opponents: Aisha and Minglu

Break 15 min

14.35- 15.15 Dissolving microneedles for vaccine delivery: Fabrication optimization and evaluation of porcine skin penetration model

Speaker: Eva Pet, Groningen University

Opponents: George and Ajla

15.15-15.55 T cell activation on a nanoporous surface for CAR-T cell manufacturing

Speaker: Matthijs Schuiling, Uppsala University

Opponents: George and Laxmipriya

16.05-16.45 Chemogenetic inhibition of dorsolateral prefrontal cortex modulates threat and reward processes relevant to affective disorders

Speaker: Naixuan Liao, Cambridge University, UK

Opponents: Prithvi and Anthi

JUNE 1

9.40 -10.20 Dissecting the effects of LIGHT in the glioblastoma microenvironment on the tissue and single-cell levels

Speaker: Saskia Franke, Uppsala University

Opponents: Sofie and Izannery

Break 15 min

10.35- 11.15 Analysis of novel bacterial species in ASTar

Speaker: Alexandra Rafeletou, Qlinea, Uppsala
Opponents: Laxmipriya and Emma

11.15- 11.55 Developing an assay to identify potent Cas9-inducible clones and evaluating its editing efficacy utilizing CRISPR-Cas9 targeting invasion genes in glioblastoma

Speaker: Faidra Voukelatou, Uppsala University
Opponents: Minglu and Neeharika

LUNCH

13.00- 13.40 Molecular link from maternal type 1 diabetes mellitus to fetal programming and offspring’s metabolic and reproductive health

Speaker: Alice Larsson, Karolinska Institute
Opponents: Paula and Tiffany

13.40- 14.20 Generation and Characterization of Human 3D-engineered Cartilage Tissues

Speaker: Patrizia Kühne, Lund University

Opponents: Anna and Mantautas

14.25- 16.30

PROGRAMME EVALUATION and CONCLUSION

UNIVERSITY PINs – PHOTO

Certificates/Jobs/PhDs

DEGREE INFORMATION

PLEASE NOTE!

EXTRA TIME on 2 June am will be used if any presentation must be postponed due to illness. Compulsory attendance.

18.00-19.00ish General Summer Closing Ceremony for Master’s students at Uppsala University

University Main Building

Remember to register ahead of time

https://www2.uu.se/en/students/degrees/closing-ceremonies

JUNE 2

PLEASE NOTE!

EXTRA TIME on 2 June am will be used if any presentation must be postponed due to illness. Compulsory attendance.

10.00-

Speaker:

Opponents:

16.00 ALL gather for procession upstairs in University main building

16.00-20ish

GRADUATION CEREMONY for MASTER’s IN MEDICAL SCIENCES

UNIVERSITY AULA , University main building

PHOTOGRAPHY

ZOOM link for supervisors, friends and families far away

Join Zoom Meeting
https://uu-se.zoom.us/j/63167409709

Meeting ID: 631 6740 9709
Passcode: Summer